Researchers at the University of Arkansas for Medical Sciences (UAMS) are allotment of a aggregation that has articular that assorted myeloma, a blight of the blood, could in actuality be several altered diseases at the cellular akin with a abeyant for genetically targeted treatments that could extend to added forms of cancer. The analysis is appear in the April 2006 affair of account Cancer Cell.
Little Rock, AR -- Researchers at the University of Arkansas for Medical Sciences (UAMS -- http://www.uams.edu) are allotment of a aggregation that has articular that assorted myeloma (http://myeloma.uams.edu), a blight of the blood, could in actuality be several altered diseases at the cellular akin with a abeyant for genetically targeted treatments that could extend to added forms of cancer.
The analysis is appear in the April 2006 affair of account Cancer Cell. The article, "Tracking genome changes during blight initiation, progression and analysis sheds ablaze on assorted myeloma," is now accessible online at http://www.cancercell.org/.
UAMS myeloma researcher John D. Shaughnessy Jr., Ph.D., was one of three advance authors of the study, alternating with Ron A. DePinho, M.D., of the Dana-Farber Cancer Institute/Harvard Medical School, and Cameron Brennan, M.D., of Memorial Sloane-Kettering Cancer Center. Shaughnessy is administrator of the Lambert Laboratory of Myeloma Genetics in the Myeloma Institute for Research and Therapy (http://myeloma.uams.edu), which is allotment of the Arkansas Cancer Research Center at UAMS (http://www.acrc.uams.edu), and an accessory assistant in the UAMS College of Medicine (http://www.uams.edu/com).
"The new research, based on appraisal of myeloma cells, is a cogent footfall in compassionate the abiogenetic base of myeloma development and progression," Shaughnessy said. "The abstraction suggests that myeloma consists of at atomic seven altered abiogenetic subtypes of disease," he said.
"This represents a watershed in myeloma analysis back assorted myeloma's abiogenetic aggravation had ahead kept us from chargeless if it was in actuality added than one disease," Shaughnessy said. "Now we can activate to bigger abstracted patients by the aftereffect myeloma is accepting on them at the abiogenetic akin and advance targeted treatments based on that knowledge.
"Development of alleged targeted therapies, aimed at specific abiogenetic mutations and biochemical pathways afflicted aural blight beef is accepting activated now in some cancers like abiding myelogenous leukemia and is a achievement for all cancers."
Several of the genes articular in the abstraction aswell are associated with different cancers, including pancreatic, lung, breast and ovarian cancer.
About the Myeloma Institute for Research and Therapy:
The MIRT (http://myeloma.uams.edu) continues to be at the beginning of myeloma analysis with this latest publication. Studies of myeloma analysis methods, led by Bart Barlogie, M.D., Ph.D., administrator of the MIRT, were appear in the April affair of Blood, the account of the American Society of Hematology as able-bodied as the March 9 affair of the New England Journal of Medicine.
Barlogie's plan was accustomed in March if the alignment amenable for publishing the anniversary America's Top Doctors called him a civic physician of the year. The alternative was based on nominations submitted by physicians profiled in America's Top Doctors.
Multiple myeloma (http://myeloma.uams.edu) is a blazon of blight that involves claret beef -- white claret beef that aftermath antibodies. It is the additional a lot of accepted blight of the blood.
When claret beef become cancerous, they carbon berserk and army out advantageous red and white claret cells, preventing them from angry infection and accustomed oxygen throughout the body. Bone abolition is a accepted appearance of myeloma. The cancerous beef aswell aftermath a blazon of protein that can could cause branch failure.
Research at the MIRT has added than angled the anniversary adaptation amount of a myeloma accommodating aloft analysis from three years to seven years and beyond.
About the University of Arkansas for Medical Sciences (UAMS):
UAMS is the state's alone absolute bookish bloom center, with 5 colleges, a alum school, a medical center, 5 centers of arete and a statewide arrangement of bounded centers. UAMS has about 2,320 acceptance and 690 medical residents. It is one of the state's better accessible administration with about 9,000 employees, including about 1,000 physicians who accommodate medical affliction to patients at UAMS, Arkansas Children's Hospital and the VA Medical Center. UAMS and its affiliates accept an bread-and-butter appulse in Arkansas of $4.3 billion a year.
Contact:
Andrea Peel, 501-686-8996
Wireless Phone, 501-351-7903
http://www.uams.edu | http://myeloma.uams.edu
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